Cannabidiol, a safe and non-psychotropic ingredient of Cannabis is protective against Inflammatory bowel disease
August 22nd, 2009 | by J.Marcu |On August 20th 2009, researchers from Italy published an article in the Journal of Molecular Medicine on the benefits of cannabidiol (CBD) to treat Inflammatory bowel disease (IBD), in a mouse model of colitis. CBD dramatically reduced tissue damage and inflammation in vivo.
The research team showed, for the first time that CBD reduced radical oxygen species (ROS) and lipid peroxidation in intestinal cells of mice. ROS production is a hallmark of IBD, as oxidative stress is the leading tissue destructive force that contributes to the development of IBD. The article also features pictures of treated and untreated intestinal tissue.
Of additional interest is the pharmacology of CBD. CBD was most effective at 5mg/kg. However, there wasn’t much difference at higher doses, even a dose of 10mg/kg did not exert a further protective effect. Lower doses (1-2.5mg/kg) were not significantly effective.
Also, the researchers found that CBD inhibited Nitric Oxide Synthase, an enzyme with produces Nitric oxide (NO). High levels of NO correlate correlate well with IBD activity, and previous experiments have shown that other Nitric Oxide Synthase Inhibitors can also improve symptoms of IBD.
Tags: Cannabidiol, CBD, IBD, inflammatory bowel disease
By JK on Aug 31, 2009
I am trying to get my city business from the city of Los Alamitos, I have secured a good lease,created Articals of Incorporations, and have all licenses but the one from the City. The City knows what type of business I will operate, ( medical supplies/ collective medical members association group )I feel like the City is stalling me unfairly, so the can create a ban on collective in their City. If anyone has any advice please offer it.